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Defensin alpha 4
mammalian protein found in Homo sapiens
corticostatin
DEFA4
neutrophil defensin 4
defensin, alpha 4, corticostatin
HP-4
HNP-4
defensin, alpha 4, preproprotein
Defensin, alpha 4
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P12838
part of
Alpha-defensin propeptide
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P12838
Beta/alpha defensin, protein family
1 reference
based on heuristic
inferred from protein domain or family
Defensin propeptide family
1 reference
based on heuristic
inferred from protein domain or family
alpha defensin
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P12838
encoded by
DEFA4
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P12838
molecular function
protein homodimerization activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Crystal structures of human alpha-defensins HNP4, HD5, and HD6
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IDA
cell component
Golgi lumen
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
TAS
extracellular region
determination method
TAS
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
azurophil granule
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IDA
extracellular space
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12838&geneProductId=UniProtKB:P12838
determination method
IEA
specific granule lumen
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
TAS
extracellular space
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
biological process
defense response
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
defense response to bacterium
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
neutrophil degranulation
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
TAS
innate immune response
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IDA
antimicrobial humoral immune response mediated by antimicrobial peptide
determination method
IC
IDA
3 references
retrieved
27 March 2018
stated in
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12838&geneProductId=UniProtKB:P12838
determination method
IDA
retrieved
27 March 2018
stated in
Crystal structures of human alpha-defensins HNP4, HD5, and HD6
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12838&geneProductId=UniProtKB:P12838
determination method
IC
retrieved
27 March 2018
stated in
Antibacterial activity and specificity of the six human {alpha}-defensins
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12838&geneProductId=UniProtKB:P12838
determination method
IC
T cell chemotaxis
determination method
IDA
1 reference
retrieved
27 March 2018
stated in
Crystal structures of human alpha-defensins HNP4, HD5, and HD6
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P12838&geneProductId=UniProtKB:P12838
determination method
IDA
antimicrobial humoral response
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
TAS
killing of cells of other organism
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
defense response to fungus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IEA
innate immune response in mucosa
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
antibacterial humoral response
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
defense response to Gram-negative bacterium
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
defense response to Gram-positive bacterium
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
membrane disruption in other organism
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
antimicrobial humoral immune response mediated by antimicrobial peptide
determination method
IBA
IDA
2 references
retrieved
8 April 2019
stated in
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
GOA
curator
UniProt
UniProt protein ID
P12838
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
cellular response to lipopolysaccharide
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12838
determination method
IBA
has part(s)
Beta/alpha defensin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P12838
Alpha defensin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P12838
Defensin propeptide
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P12838
Identifiers
RefSeq protein ID
NP_001916
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1669
UniProt protein ID
P12838
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P12838
Ensembl protein ID
ENSP00000297435
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000297435
ENSP00000493844
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000493844
PDB structure ID
1ZMM
1 reference
stated in
UniProt
UniProt protein ID
P12838
retrieved
21 March 2016
language of work or name
English
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