(Q21108632)

1 reference

1 January 2018

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

1 reference

17 October 2017

protein binding

1 reference

1 January 2018

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

Wnt-protein binding

Wnt-activated receptor activity

NAS

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

5 references

1 January 2018

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

cell component

cytoplasm

1 reference

1 January 2018

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

clathrin-coated endocytic vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

TAS

focal adhesion

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

17 October 2017

17 October 2017

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

integral component of membrane

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

1 January 2018

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

focal adhesion

HDA

1 reference

1 January 2018

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

G protein-coupled receptor signaling pathway

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

epithelial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

muscular septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

ventricular septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

cell-cell signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

membranous septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

outflow tract morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

positive regulation of DNA-binding transcription factor activity

1 reference

1 January 2018

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

planar cell polarity pathway involved in neural tube closure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

positive regulation of transcription, DNA-templated

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

sensory perception of smell

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

inner ear receptor cell development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

hard palate development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

cochlea morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

canonical Wnt signaling pathway

ISS

4 references

17 October 2017

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

17 October 2017

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

17 October 2017

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

17 October 2017

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14332&geneProductId=UniProtKB:Q14332

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

beta-catenin destruction complex disassembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

Wnt signaling pathway, calcium modulating pathway

TAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

1 January 2018

non-canonical Wnt signaling pathway

TAS

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

positive regulation of G protein-coupled receptor signaling pathway

IMP

1 reference

1 January 2018

cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

canonical Wnt signaling pathway

IMP

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14332

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14332

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14332

Frizzled/Smoothened, transmembrane domain

1 reference

InterPro Release 71.0