(Q21108844)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99571

P2X4 purinoceptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99571

P2X purinoreceptor

1 reference

Transporter Classification Database ID

1.A.7.1.5

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

protein homodimerization activity

1 reference

31 October 2017

Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

cadherin binding

1 reference

31 October 2017

P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

purinergic nucleotide receptor activity

A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

extracellularly ATP-gated cation channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

4 references

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

Site-specific splice variation of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

1 reference

31 October 2017

protein binding

1 reference

31 October 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

3 references

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

identical protein binding

IC

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

1 reference

31 October 2017

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

postsynaptic density

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

dendritic spine

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

integral component of nuclear inner membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

1 reference

31 October 2017

IBA

synapse

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

integral component of plasma membrane

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

Site-specific splice variation of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

31 October 2017

A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

IC

lysosomal membrane

1 reference

31 October 2017

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

cell junction

1 reference

31 October 2017

P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

soma

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

terminal bouton

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

axon

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

dendrite

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

perinuclear region of cytoplasm

1 reference

31 October 2017

P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

extracellular exosome

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

4 references

31 October 2017

31 October 2017

Evidence for functional P2X4/P2X7 heteromeric receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

31 October 2017

A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

positive regulation of calcium-mediated signaling

biological process

positive regulation of calcium ion transport into cytosol

negative regulation of cardiac muscle hypertrophy

1 reference

31 October 2017

A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

positive regulation of nitric oxide biosynthetic process

1 reference

31 October 2017

P2X(4) receptors mediate ATP-induced calcium influx in human vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

membrane depolarization

1 reference

31 October 2017

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

endothelial cell activation

1 reference

31 October 2017

P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

cation transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

1 reference

31 October 2017

response to fluid shear stress

1 reference

31 October 2017

Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

regulation of blood pressure

ion transmembrane transport

1 reference

31 October 2017

Site-specific splice variation of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

positive regulation of prostaglandin secretion

1 reference

31 October 2017

P2X(4) receptors mediate ATP-induced calcium influx in human vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

tissue homeostasis

1 reference

31 October 2017

Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

apoptotic signaling pathway

1 reference

31 October 2017

Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

regulation of cardiac muscle contraction

cellular response to ATP

1 reference

31 October 2017

Site-specific splice variation of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

protein homooligomerization

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

relaxation of cardiac muscle

signal transduction

1 reference

31 October 2017

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

neuronal action potential

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

purinergic nucleotide receptor signaling pathway

1 reference

31 October 2017

A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

positive regulation of calcium ion transport

1 reference

31 October 2017

A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

blood coagulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

1 reference

31 October 2017

excitatory postsynaptic potential

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

positive regulation of blood vessel endothelial cell migration

1 reference

31 October 2017

Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

positive regulation of endothelial cell chemotaxis

1 reference

31 October 2017

Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99571&geneProductId=UniProtKB:Q99571

physically interacts with

adenosine triphosphate

has use

agonist

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1713

language of work or name

English

Transporter Classification Database ID

17 August 2016

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1.A.7.1.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database