(Q21109233)

English

Cell division cycle 25A

mammalian protein found in Homo sapiens

CDC25A2-CAG isoform
dual specificity phosphatase CDC25A
M-phase inducer phosphatase 1
Cell division cycle 25A, isoform CRA_a
CDC25A
CDC25 isoform A1-CAG

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Statements

1 reference

13 November 2019

1 reference

22 April 2020

1 reference

22 April 2020

determination method or standard

IPI

5 references

retrieved

8 April 2019

stated in

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

retrieved

8 April 2019

stated in

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

retrieved

8 April 2019

stated in

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

retrieved

8 April 2019

stated in

14-3-3 proteins associate with cdc25 phosphatases

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

retrieved

8 April 2019

stated in

Short 42 degrees C heat shock induces phosphorylation and degradation of Cdc25A which depends on p38MAPK, Chk2 and 14.3.3.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

protein tyrosine phosphatase activity

determination method or standard

IEA

hydrolase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IEA

protein kinase binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

chaperone binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IPI

protein tyrosine phosphatase activity

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IBA

cell component

cytosol

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

TAS

nucleoplasm

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

TAS

biological process

cellular response to UV

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IDA

regulation of cell cycle

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

TAS

G2/M transition of mitotic cell cycle

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30304&geneProductId=UniProtKB:P30304

determination method or standard

TAS

cell cycle

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IEA

response to radiation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IDA

cell population proliferation

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

TAS

protein deubiquitination

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

TAS

G1/S transition of mitotic cell cycle

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

TAS

positive regulation of G2/M transition of mitotic cell cycle

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IBA

positive regulation of mitotic cell cycle

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IBA

positive regulation of G2/MI transition of meiotic cell cycle

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30304

determination method or standard

IBA

has part(s)

Rhodanese-like domain

2 references

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P30304

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/A0A024R2S4

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

22 April 2020

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

language of work or name

English

(Q21109233)

Cell division cycle 25A

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