Wikidata

(Q21109244)

English

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

mammalian protein found in Homo sapiens

  • KCIP-1
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
  • epididymis secretory protein Li 1
  • protein 1054
  • YWHAB
  • 14-3-3 alpha
  • protein kinase C inhibitor protein-1
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
  • Protein kinase C inhibitor protein 1
  • 14-3-3 protein beta/alpha
  • brain protein 14-3-3, beta isoform
In more languages

Statements

molecular function
protein binding
determination method
IPI
67 references
retrieved
1 January 2018
stated in
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in α1-adrenergic receptor-induced p38 activation
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner
GOA
curator
UniProt
UniProt protein ID
P31946
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
14-3-3 proteins associate with cdc25 phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Direct and heterologous approaches to identify the LET-756/FGF interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis for protein-protein interactions in the 14-3-3 protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Activation of Raf-1 by 14-3-3 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
retrieved
1 January 2018
stated in
Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31946
determination method
IPI
cell component
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21109244&oldid=2022936630"