Wikidata

(Q21109662)

English

Filamin A

mammalian protein found in Homo sapiens

  • endothelial actin-binding protein
  • non-muscle filamin
  • FLNA
  • epididymis secretory sperm binding protein
  • filamin A, alpha
  • Actin-binding protein 280
  • filamin-1
  • filamin-A
  • alpha-filamin
  • ABP-280
  • actin binding protein 280
In more languages

Statements

molecular function
protein binding
determination method
IDA
IPI
32 references
retrieved
17 October 2017
stated in
Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
A meckelin-filamin A interaction mediates ciliogenesis
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Identification of novel nuclear protein interactions with the N-terminal part of filamin A
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Structural mechanism of integrin inactivation by filamin.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Filamin A regulates cell spreading and survival via beta1 integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
The small GTPase RalA targets filamin to induce filopodia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IPI
retrieved
17 October 2017
stated in
Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc Receptor I (FcγRI)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
retrieved
17 October 2017
stated in
Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
cell component
extracellular exosome
determination method
IDA
5 references
retrieved
17 October 2017
stated in
Large-scale proteomics and phosphoproteomics of urinary exosomes
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
retrieved
17 October 2017
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
retrieved
17 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
retrieved
17 October 2017
stated in
Protein profile of exosomes from trabecular meshwork cells
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
P21333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P21333&geneProductId=UniProtKB:P21333
determination method
IDA
biological process

Identifiers

PDB structure ID
 
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