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Deltex E3 ubiquitin ligase 1
mammalian protein found in Homo sapiens
RING-type E3 ubiquitin transferase DTX1
deltex1
E3 ubiquitin-protein ligase DTX1
deltex 1, E3 ubiquitin ligase
protein deltex-1
hDTX1
deltex homolog 1
DTX1
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Y01
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Y01
encoded by
DTX1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Y01
molecular function
SH3 domain binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
transcription coactivator activity
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Human deltex is a conserved regulator of Notch signalling
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
TAS
zinc ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
protein binding
determination method
IPI
3 references
retrieved
8 April 2019
stated in
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IPI
retrieved
8 April 2019
stated in
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IPI
retrieved
8 April 2019
stated in
The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IPI
ubiquitin protein ligase binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IPI
metal ion binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
Notch binding
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IDA
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
cell component
cytoplasm
determination method
TAS
IEA
2 references
retrieved
8 April 2019
stated in
Human deltex is a conserved regulator of Notch signalling
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
nucleus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
nucleoplasm
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IDA
cytosol
determination method
IDA
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IDA
nuclear body
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IDA
biological process
Notch signaling pathway
determination method
TAS
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
cell surface receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Human deltex is a conserved regulator of Notch signalling
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
TAS
glial cell differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
transcription by RNA polymerase II
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Human deltex is a conserved regulator of Notch signalling
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
TAS
regulation of Notch signaling pathway
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IGI
negative regulation of T cell differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
negative regulation of neuron differentiation
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IGI
protein ubiquitination
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
transcription, DNA-templated
determination method
NAS
1 reference
retrieved
8 April 2019
stated in
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
GOA
curator
UniProt
UniProt protein ID
Q86Y01
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
NAS
cellular response to leukemia inhibitory factor
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
positive regulation of nucleic acid-templated transcription
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y01
determination method
IEA
Identifiers
RefSeq protein ID
NP_004407
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1840
XP_011536311
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1840
UniProt protein ID
Q86Y01
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Y01
Ensembl protein ID
ENSP00000257600
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000257600
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