(Q21110110)

http://www.ebi.ac.uk/interpro/protein/P49770

Initiation factor 2B-related

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49770

1 reference

13 November 2019

1 reference

13 November 2019

guanyl-nucleotide exchange factor activity

1 reference

9 May 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

3 references

9 May 2019

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Next-generation sequencing to generate interactome datasets

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

translation initiation factor activity

IDA

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

An efficient mammalian cell-free translation system supplemented with translation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

guanyl-nucleotide exchange factor activity

3 references

9 May 2019

Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

eukaryotic translation initiation factor 2B complex

TAS

eukaryotic translation initiation factor 2B complex

IDA

3 references

9 May 2019

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

response to peptide hormone

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

central nervous system development

ISS

1 reference

9 May 2019

Identification of ten novel mutations in patients with eIF2B-related disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

ovarian follicle development

IEA

1 reference

9 May 2019

Screening for known mutations in EIF2Bgenes in a large panel of patients with premature ovarian failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

oligodendrocyte development

IMP

1 reference

9 May 2019

The life and death of oligodendrocytes in vanishing white matter disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

regulation of translational initiation

IMP

1 reference

8 April 2019

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

T cell receptor signaling pathway

IEA

1 reference

9 May 2019

T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

IDA

translational initiation

3 references

9 May 2019

9 May 2019

An efficient mammalian cell-free translation system supplemented with translation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49770

regulation of translational initiation