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(Q21111115)
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Insulin induced gene 2
mammalian protein found in Homo sapiens
insulin-induced gene 2 protein
INSIG2
insulin induced protein 2
INSIG2 membrane protein
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y5U4
part of
Insulin-induced protein family
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y5U4
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y5U4
encoded by
INSIG2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y5U4
molecular function
transcription factor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
protein binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IPI
cell component
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
SREBP-SCAP-Insig complex
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
endoplasmic reticulum
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
endoplasmic reticulum membrane
determination method
IEA
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
biological process
roof of mouth development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
steroid metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
response to fatty acid
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
sterol biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
negative regulation of fatty acid biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
lipid metabolism
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
cholesterol metabolic process
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
response to sterol depletion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
cranial suture morphogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
response to insulin
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
response to lipid
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
inner ear morphogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
middle ear morphogenesis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
SREBP signaling pathway
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q9Y5U4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IDA
cholesterol biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
triglyceride metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
negative regulation of steroid biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y5U4
determination method
IEA
Identifiers
RefSeq protein ID
NP_001308258
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
51141
NP_001308259
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
51141
NP_001308260
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
51141
NP_001308261
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
51141
NP_001308262
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
51141
NP_057217
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
51141
UniProt protein ID
Q9Y5U4
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y5U4
Ensembl protein ID
ENSP00000245787
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000245787
ENSP00000400126
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000400126
ENSP00000484179
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000484179
PDB structure ID
4J82
1 reference
stated in
Swiss-Prot
UniProt
retrieved
14 November 2015
reference URL
http://www.uniprot.org/uniprot/Q9Y5U4.txt?version=93
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