Wikidata

(Q21111152)

English

Cullin 3

mammalian protein found in Homo sapiens

  • CUL3
  • cullin-3
In more languages

Statements

molecular function
protein binding
determination method
IPI
25 references
retrieved
8 April 2019
stated in
A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of TIP60 by ATF2 modulates ATM activation
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
TIP120A associates with cullins and modulates ubiquitin ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
retrieved
8 April 2019
stated in
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IPI
cell component
Cul3-RING ubiquitin ligase complex
determination method
IDA
14 references
retrieved
8 April 2019
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Ubiquitin-dependent regulation of COPII coat size and function
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Translational homeostasis via the mRNA cap-binding protein, eIF4E
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Control of rapsyn stability by the CUL-3-containing E3 ligase complex
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Cell-fate determination by ubiquitin-dependent regulation of translation
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
biological process
protein ubiquitination
determination method
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IEA
retrieved
8 April 2019
stated in
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA
retrieved
8 April 2019
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
UniProt
UniProt protein ID
Q13618
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13618
determination method
IDA

Identifiers

 
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