(Q21111174)

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

Nicotinic acetylcholine receptor

1 reference

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

acetylcholine receptor activity

1 reference

16 July 2018

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

1 reference

8 April 2019

ligand-gated ion channel activity

1 reference

8 April 2019

Low ethanol concentration alters CHRNA5 RNA levels during early human development

GOA

curator

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

extracellular ligand-gated ion channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

1 reference

16 July 2018

protein binding

IPI

1 reference

8 April 2019

Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

acetylcholine-gated cation-selective channel activity

IPI

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

Low ethanol concentration alters CHRNA5 RNA levels during early human development

GOA

curator

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

8 April 2019

PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

1 reference

8 April 2019

acetylcholine receptor activity

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

acetylcholine-gated channel complex

cell component

Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

16 July 2018

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

integral component of membrane

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

plasma membrane

synapse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

1 reference

16 July 2018

integral component of plasma membrane

IC

1 reference

16 July 2018

Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

IC

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

1 reference

8 April 2019

neuron projection

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

specific granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

1 reference

8 April 2019

tertiary granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

1 reference

8 April 2019

integral component of plasma membrane

acetylcholine-gated channel complex

IC

Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

cholinergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

smooth muscle contraction

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

protein heterooligomerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

positive regulation of transmission of nerve impulse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

regulation of membrane potential

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

synaptic transmission, cholinergic

1 reference

16 July 2018

Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

ion transport

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

8 April 2019

regulation of neurotransmitter secretion

NAS

1 reference

8 April 2019

Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

behavioral response to nicotine

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

action potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

signal transduction

1 reference

16 July 2018

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

1 reference

8 April 2019

regulation of postsynaptic membrane potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

excitatory postsynaptic potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30926&geneProductId=UniProtKB:P30926

1 reference

16 July 2018

signal transduction

chemical synaptic transmission

2 references

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

neuromuscular synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

nervous system process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30926

physically interacts with

larazotide acetate

object of statement has role

Partial agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103815

has part(s)

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

Neurotransmitter-gated ion-channel ligand-binding domain

1 reference

Neurotransmitter-gated ion-channel, conserved site

1 reference

http://www.uniprot.org/uniprot/P30926.txt?version=159

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

14 November 2015

Transporter Classification Database ID

1.A.9.1.6

1 reference