Wikidata

(Q21111280)

English

TANK binding kinase 1

mammalian protein found in Homo sapiens

  • serine/threonine-protein kinase TBK1
  • T2K
  • NF-kB-activating kinase
  • TBK1
  • NF-kappa-B-activating kinase
  • TANK-binding kinase 1
In more languages

Statements

molecular function
protein serine/threonine kinase activity
determination method
IDA
IEA
TAS
7 references
retrieved
27 March 2018
stated in
Emerging roles for the non-canonical IKKs in cancer
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
TAS
retrieved
27 March 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
TAS
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
IEA
retrieved
27 March 2018
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
IDA
retrieved
27 March 2018
stated in
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
IDA
retrieved
27 March 2018
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UHD2&geneProductId=UniProtKB:Q9UHD2
determination method
IDA
protein binding
determination method
IPI
40 references
retrieved
8 April 2019
stated in
WDFY1 mediates TLR3/4 signaling by recruiting TRIF
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
MAVS protein is attenuated by rotavirus nonstructural protein 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
The TBK1-binding domain of optineurin promotes type I interferon responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Expanding the substantial interactome of NEMO using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-induced Innate Immunity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Activation of STAT6 by STING is critical for antiviral innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IPI
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
TAS
9 references
retrieved
8 April 2019
stated in
Emerging roles for the non-canonical IKKs in cancer
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IEA
retrieved
8 April 2019
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IDA
retrieved
8 April 2019
stated in
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
GOA
curator
UniProt
UniProt protein ID
Q9UHD2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IDA
retrieved
8 April 2019
stated in
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IDA
retrieved
8 April 2019
stated in
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UHD2
determination method
IBA
biological process

Identifiers

 
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