Wikidata

(Q21111538)

English

Inhibitor of nuclear factor kappa B kinase subunit epsilon

mammalian protein found in Homo sapiens

  • inhibitor of nuclear factor kappa-B kinase subunit epsilon
  • I-kappa-B kinase epsilon
  • IKBKE
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • IKK-i
  • IKK-related kinase epsilon
  • inducible IkappaB kinase
  • inducible I kappa-B kinase
  • IKK-epsilon
In more languages

Statements

molecular function
protein binding
determination method
IPI
21 references
retrieved
8 April 2019
stated in
SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death
GOA
curator
UniProt
UniProt protein ID
Q14164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
GOA
curator
UniProt
UniProt protein ID
Q14164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
GOA
curator
UniProt
UniProt protein ID
Q14164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
GOA
curator
UniProt
UniProt protein ID
Q14164
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-induced Innate Immunity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14164
determination method
IPI
cell component
biological process

Identifiers

 
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