(Q21111613)

http://www.ebi.ac.uk/interpro/protein/P50553

Helix-loop-helix DNA-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P50553

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

protein dimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

DNA-binding transcription repressor activity, RNA polymerase II-specific

IDA

2 references

10 September 2018

Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

8 April 2019

Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

1 reference

8 April 2019

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

double-stranded DNA binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

2 references

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

DNA-binding transcription factor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

transcription factor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

Mechanisms of neuroendocrine differentiation in pulmonary neuroendocrine cells and small cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

Human ASH1 expression in prostate cancer with neuroendocrine differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

RNA polymerase II transcription regulator complex

IDA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

commitment of neuronal cell to specific neuron type in forebrain

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

pattern specification process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

cerebral cortex GABAergic interneuron differentiation

1 reference

8 April 2019

Origin of GABAergic neurons in the human neocortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

stomach neuroendocrine cell differentiation

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

spinal cord association neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

sympathetic nervous system development

1 reference

8 April 2019

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

neuroblast fate determination

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

spinal cord oligodendrocyte cell fate specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

musculoskeletal movement, spinal reflex action

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

negative regulation of apoptotic process

1 reference

8 April 2019

Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

glial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

cellular response to magnetism

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

oligodendrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

olfactory pit development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

lung neuroendocrine cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

generation of neurons

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

response to lithium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

positive regulation of neural precursor cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

adrenal chromaffin cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

positive regulation of neurogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

positive regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

central nervous system neuron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

positive regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

response to epidermal growth factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

vestibular nucleus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of mitotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

forebrain neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

cerebral cortex development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

neuroblast proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

subpallium neuron fate commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of timing of subpallium neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

oligodendrocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

lung epithelial cell differentiation

1 reference

8 April 2019

Mechanisms of neuroendocrine differentiation in pulmonary neuroendocrine cells and small cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

carotid body glomus cell differentiation

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

response to folic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

spinal cord oligodendrocyte cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of epithelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

noradrenergic neuron fate commitment

IDA

1 reference

8 April 2019

Noradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation syndrome (Ondine's curse)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of Notch signaling pathway

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of neurogenesis

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50553&geneProductId=UniProtKB:P50553

positive regulation of Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

oligodendrocyte cell fate commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

regulation of transcription by RNA polymerase II

sensory organ development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

positive regulation of transcription by RNA polymerase II

neuron differentiation

3 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50553

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

stated in

InterPro Release 71.0