(Q21111738)

http://www.ebi.ac.uk/interpro/protein/Q9Y572

RHIM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

RIP3, a novel apoptosis-inducing kinase

protein kinase activity

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

transcription coactivator activity

1 reference

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

protein serine/threonine kinase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

NF-kappaB-inducing kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

11 references

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

identical protein binding

IPI

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

2 references

protein-containing complex binding

1 reference

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

intracellular anatomical structure

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y572&geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

biological process

amyloid fibril formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

protein heterooligomerization

IMP

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of oxidoreductase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of phosphatase activity

1 reference

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of necroptotic process

IMP

3 references

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

protein phosphorylation

1 reference

8 April 2019

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

NIK/NF-kappaB signaling

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

apoptotic signaling pathway

1 reference

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

protein autophosphorylation

TAS

1 reference

8 April 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of ligase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

protein homooligomerization

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

activation of protein kinase activity

1 reference

8 April 2019

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of intrinsic apoptotic signaling pathway

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

1 reference

8 April 2019

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

TAS

programmed cell death

1 reference

8 April 2019

positive regulation of necrotic cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572

positive regulation of nucleic acid-templated transcription

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y572