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(Q21111934)
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Cytokine inducible SH2 containing protein
mammalian protein found in Homo sapiens
cytokine-inducible inhibitor of signaling type 1B
suppressor of cytokine signaling
SOCS
Protein G18
CISH
CIS-1
cytokine-inducible SH2-containing protein
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NSE2
part of
Cytokine-inducible SH2-containing protein
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NSE2
SOCS box-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NSE2
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NSE2
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
CIS, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SOCS box domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NSE2
encoded by
CISH
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NSE2
molecular function
protein kinase inhibitor activity
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NSE2&geneProductId=UniProtKB:Q9NSE2
determination method
IBA
protein binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IPI
molecular function
determination method
ND
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
ND
1-phosphatidylinositol-3-kinase regulator activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IBA
cell component
cytoplasm
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NSE2&geneProductId=UniProtKB:Q9NSE2
determination method
IBA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
TAS
plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
cellular component
determination method
ND
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
ND
phosphatidylinositol 3-kinase complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IBA
biological process
regulation of growth
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
negative regulation of insulin receptor signaling pathway
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IBA
protein kinase C-activating G protein-coupled receptor signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
intracellular signal transduction
determination method
NAS
IEA
2 references
retrieved
8 April 2019
stated in
Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
negative regulation of signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
regulation of cell growth
determination method
NAS
1 reference
retrieved
8 April 2019
stated in
Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
NAS
protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NSE2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
negative regulation of protein kinase activity
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NSE2&geneProductId=UniProtKB:Q9NSE2
determination method
IBA
negative regulation of receptor signaling pathway via JAK-STAT
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NSE2&geneProductId=UniProtKB:Q9NSE2
determination method
IBA
cytokine-mediated signaling pathway
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NSE2&geneProductId=UniProtKB:Q9NSE2
determination method
IBA
post-translational protein modification
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
TAS
interleukin-7-mediated signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
TAS
regulation of phosphatidylinositol 3-kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IEA
phosphatidylinositol phosphate biosynthetic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSE2
determination method
IBA
has part(s)
SOCS box domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NSE2
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NSE2
CIS, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NSE2
Identifiers
RefSeq protein ID
NP_037456
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1154
NP_659508
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1154
XP_011531631
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1154
UniProt protein ID
Q9NSE2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NSE2
Ensembl protein ID
ENSP00000294173
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000294173
ENSP00000409346
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000409346
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