Wikidata

(Q21112127)

English

OTU deubiquitinase with linear linkage specificity

mammalian protein found in Homo sapiens

  • deubiquitinating enzyme otulin
  • OTULIN
  • ubiquitin thioesterase otulin
  • family with sequence similarity 105, member B
  • OTU domain-containing deubiquitinase with linear linkage specificity
  • ubiquitin thioesterase Gumby
In more languages

Statements

molecular function
thiol-dependent deubiquitinase
determination method
IEA
IDA
10 references
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
16 July 2018
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
thiol-dependent deubiquitinase
determination method
IBA
IDA
IEA
11 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
8 April 2019
stated in
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IBA
cell component
biological process
protein linear deubiquitination
determination method
IEA
IDA
10 references
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
16 July 2018
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
negative regulation of NF-kappaB transcription factor activity
determination method
IDA
IEA
IMP
6 references
retrieved
16 July 2018
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
16 July 2018
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
16 July 2018
stated in
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
16 July 2018
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BN8&geneProductId=UniProtKB:Q96BN8
determination method
IDA
negative regulation of NF-kappaB transcription factor activity
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
8 April 2019
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
8 April 2019
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IBA
negative regulation of inflammatory response
determination method
IBA
IEA
IMP
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
ISS
retrieved
8 April 2019
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
8 April 2019
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
8 April 2019
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IBA
protein linear deubiquitination
determination method
IBA
IDA
IEA
11 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IEA
retrieved
8 April 2019
stated in
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
GOA
curator
UniProt
UniProt protein ID
Q96BN8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BN8
determination method
IBA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21112127&oldid=2022948334"