Wikidata

(Q21112836)

English

Phosphatidylinositol 3-kinase catalytic subunit type 3

mammalian protein found in Homo sapiens

  • phosphatidylinositol 3-kinase p100 subunit
  • phosphatidylinositol 3-kinase catalytic subunit type 3
  • phosphoinositide-3-kinase, class 3
  • PI3-kinase type 3
  • hVps34
  • PI3K type 3
  • Phosphoinositide-3-kinase class 3
  • PtdIns-3-kinase type 3
  • PIK3C3
In more languages
default values for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
25 references
retrieved
8 April 2019
stated in
Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Human VPS34 and p150 are Rab7 Interacting Partners
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
NRBF2 regulates macroautophagy as a component of Vps34 Complex I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a candidate therapeutic autophagy-inducing peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
A kinase-independent role for EGF receptor in autophagy initiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
The VMP1-Beclin 1 interaction regulates autophagy induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
retrieved
8 April 2019
stated in
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IPI
1-phosphatidylinositol-3-kinase activity
determination method
IBA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
TAS
retrieved
8 April 2019
stated in
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
TAS
retrieved
8 April 2019
stated in
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8NEB9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NEB9
determination method
IBA
cell component
biological process

Identifiers

 
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