(Q21113622)

English

MAP kinase activating death domain

mammalian protein found in Homo sapiens

MADD
Rab3 GDP/GTP exchange factor
insulinoma glucagonoma clone 20
MAP kinase-activating death domain protein
differentially expressed in normal and neoplastic cells

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Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

death receptor binding

1 reference

8 April 2019

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

TAS

guanyl-nucleotide exchange factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IEA

protein kinase activator activity

1 reference

8 April 2019

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

3 references

8 April 2019

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

8 April 2019

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IPI

cell component

integral component of membrane

1 reference

8 April 2019

DENN, a novel human gene differentially expressed in normal and neoplastic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IDA

biological process

regulation of apoptotic process

1 reference

8 April 2019

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IMP

regulation of extrinsic apoptotic signaling pathway

1 reference

8 April 2019

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IDA

execution phase of apoptosis

1 reference

8 April 2019

Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IMP

regulation of tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

TAS

regulation of Rab protein signal transduction

1 reference

5 June 2018

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXG6&geneProductId=UniProtKB:Q8WXG6

determination method

IDA

regulation of cell cycle

1 reference

8 April 2019

Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IMP

cell surface receptor signaling pathway

1 reference

8 April 2019

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

TAS

regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

5 June 2018

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WXG6&geneProductId=UniProtKB:Q8WXG6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WXG6

determination method

IEA

regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

IBA

IMP

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(Q21113622)

MAP kinase activating death domain

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