Wikidata

(Q21113662)

English

NCK adaptor protein 1

mammalian protein found in Homo sapiens

  • non-catalytic region of tyrosine kinase
  • cytoplasmic protein NCK1
  • Nck-1
  • NCK tyrosine kinase
  • NCK1
  • melanoma NCK protein
  • SH2/SH3 adaptor protein NCK-alpha
In more languages

Statements

molecular function
protein binding
determination method
IPI
28 references
retrieved
8 April 2019
stated in
Nck-1 interacts with PKR and modulates its activation by dsRNA
GOA
curator
UniProt
UniProt protein ID
P16333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
GOA
curator
UniProt
UniProt protein ID
P16333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta
GOA
curator
UniProt
UniProt protein ID
P16333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
GOA
curator
UniProt
UniProt protein ID
P16333
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of interactions of Nck with Sos and dynamin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitylation-dependent downregulation of Nck regulates its functional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
retrieved
8 April 2019
stated in
Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16333
determination method
IPI
cell component
biological process

Identifiers

 
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