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(Q21114445)
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English
Enhancer of zeste 1 polycomb repressive complex 2 subunit
mammalian protein found in Homo sapiens
histone-lysine N-methyltransferase EZH1
ENX-2
enhancer of zeste homolog 1
EZH1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q92800
part of
Histone-lysine N-methyltransferase EZH1
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q92800
SANT/Myb domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Tesmin/TSO1-like CXC domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
CXC domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SET domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q92800
encoded by
EZH1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q92800
molecular function
methyltransferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
chromatin binding
determination method
IEA
TAS
2 references
retrieved
8 April 2019
stated in
Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
histone-lysine N-methyltransferase activity
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method
ISM
NAS
2 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
ISM
DNA binding
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
ISS
transcription corepressor activity
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
ISS
cell component
ESC/E(Z) complex
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IDA
nucleus
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
nucleoplasm
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IDA
telomere
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
ISS
biological process
histone H3-K27 methylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
anatomical structure morphogenesis
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
TAS
methylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92800&geneProductId=UniProtKB:Q92800
determination method
IEA
hippocampus development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
transcription, DNA-templated
determination method
IEA
1 reference
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92800&geneProductId=UniProtKB:Q92800
determination method
IEA
positive regulation of transcription by RNA polymerase II
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
chromatin organization
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92800
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
IEA
negative regulation of transcription by RNA polymerase II
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
ISS
chromatin remodeling
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92800
determination method
ISS
exact match
https://identifiers.org/uniprot:Q92800
1 reference
stated in
Identifiers.org
UniProt protein ID
Q92800
reference URL
https://registry.identifiers.org/registry/uniprot
http://purl.uniprot.org/uniprot/Q92800
1 reference
stated in
Identifiers.org
UniProt protein ID
Q92800
reference URL
https://registry.identifiers.org/registry/uniprot
https://www.ncbi.nlm.nih.gov/protein/Q92800
1 reference
stated in
Identifiers.org
UniProt protein ID
Q92800
reference URL
https://registry.identifiers.org/registry/uniprot
has part(s)
SET domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q92800
Tesmin/TSO1-like CXC domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q92800
SANT/Myb domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q92800
CXC domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q92800
Identifiers
RefSeq protein ID
NP_001308008
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
NP_001308010
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
NP_001308011
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
NP_001982
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
XP_005257202
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
XP_011522819
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
XP_016879839
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
XP_016879840
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
XP_016879841
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
2145
UniProt protein ID
Q92800
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q92800
Ensembl protein ID
ENSP00000404658
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000404658
ENSP00000465220
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000465220
ENSP00000466924
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000466924
ENSP00000467871
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000467871
ENSP00000407869
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000407869
ENSP00000464753
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000464753
ENSP00000465327
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000465327
ENSP00000465423
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000465423
ENSP00000465482
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000465482
ENSP00000466393
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000466393
ENSP00000467036
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000467036
ENSP00000467320
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000467320
ENSP00000468640
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000468640
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