(Q21114501)

http://www.ebi.ac.uk/interpro/protein/O14713

Integrin binding protein, ICAP-1

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14713

PTB/PI domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

9 references

8 April 2019

ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Phospho-tyrosine dependent protein-protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

GDP-dissociation inhibitor activity

IPI

1 reference

8 April 2019

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

protein-containing complex binding

1 reference

1 January 2018

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

2 references

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

perinuclear region of cytoplasm

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

microtubule organizing center

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

biological process

Notch signaling pathway

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

activation of protein kinase B activity

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

intracellular signal transduction

1 reference

8 April 2019

Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

positive regulation of protein kinase B signaling

TAS

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

regulation of transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14713&geneProductId=UniProtKB:O14713

negative regulation of protein kinase activity

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

regulation of GTPase activity

1 reference

8 April 2019

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

biomineral tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

negative regulation of protein binding

1 reference

8 April 2019

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

cellular response to fibroblast growth factor stimulus

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14713&geneProductId=UniProtKB:O14713

positive regulation of endothelial cell migration

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

negative regulation of cell migration involved in sprouting angiogenesis

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

negative regulation of protein targeting to membrane

1 reference

8 April 2019

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

positive regulation of cell population proliferation

1 reference

8 April 2019

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

1 January 2018

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

integrin-mediated signaling pathway

2 references

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

8 April 2019

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

negative regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

positive regulation of focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

cellular response to vascular endothelial growth factor stimulus

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

positive regulation of cell division

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

positive regulation of Notch signaling pathway

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

negative regulation of cell population proliferation

1 reference

8 April 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

positive regulation of transcription by RNA polymerase II

protein localization to plasma membrane

1 reference

8 April 2019

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14713

1 reference

InterPro Release 71.0