Wikidata

(Q21114550)

English

T-box transcription factor 5

mammalian protein found in Homo sapiens

  • T-box transcription factor TBX5
  • TBX5
  • T-box protein 5
  • T-box 5
In more languages

Statements

molecular function
protein binding
determination method
IPI
9 references
retrieved
8 April 2019
stated in
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
GATA4 loss-of-function mutations underlie familial tetralogy of fallot
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
retrieved
8 April 2019
stated in
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IPI
DNA-binding transcription factor activity
determination method
IEA
IDA
IMP
6 references
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
cell component
nucleus
determination method
IEA
IDA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
Induction of apoptosis and inhibition of cell growth by developmental regulator hTBX5
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
TBX5 nuclear localization is mediated by dual cooperative intramolecular signals
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
biological process
heart development
determination method
IEA
IDA
IMP
7 references
retrieved
8 April 2019
stated in
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IMP
retrieved
8 April 2019
stated in
A novel TBX5 loss-of-function mutation associated with sporadic dilated cardiomyopathy
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IMP
retrieved
8 April 2019
stated in
TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IMP
retrieved
8 April 2019
stated in
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IMP
retrieved
8 April 2019
stated in
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
A role for Tbx5 in proepicardial cell migration during cardiogenesis
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
positive regulation of transcription, DNA-templated
determination method
IEA
IDA
6 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IEA
retrieved
8 April 2019
stated in
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA
retrieved
8 April 2019
stated in
TBX5 loss-of-function mutation contributes to atrial fibrillation and atypical Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
Q99593
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99593
determination method
IDA

Identifiers

 
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