Wikidata

(Q21115605)

English

Fms related receptor tyrosine kinase 1

mammalian protein found in Homo sapiens

  • vascular endothelial growth factor receptor 1
  • fms-like tyrosine kinase 1
  • vascular permeability factor receptor
  • FLT1
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • tyrosine-protein kinase FRT
  • FLT-1
  • FLT
  • tyrosine-protein kinase receptor FLT
  • fms related tyrosine kinase 1
In more languages

Statements

part of
molecular function
vascular endothelial growth factor-activated receptor activity
determination method
IDA
IEA
IMP
TAS
5 references
retrieved
26 September 2017
stated in
Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948
determination method
TAS
retrieved
26 September 2017
stated in
Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948
determination method
IMP
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948
determination method
IEA
retrieved
26 September 2017
stated in
The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948
determination method
IDA
retrieved
26 September 2017
stated in
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P17948&geneProductId=UniProtKB:P17948
determination method
IDA
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
growth factor binding
determination method
IPI
5 references
retrieved
8 April 2019
stated in
Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the VEGF binding site on the Flt-1 receptor
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
retrieved
8 April 2019
stated in
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IPI
vascular endothelial growth factor-activated receptor activity
determination method
IBA
IDA
IEA
IMP
TAS
6 references
retrieved
8 April 2019
stated in
Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
TAS
retrieved
8 April 2019
stated in
Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IEA
retrieved
8 April 2019
stated in
The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
GOA
curator
UniProt
UniProt protein ID
P17948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IDA
retrieved
8 April 2019
stated in
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17948
determination method
IBA
cell component
biological process
physically interacts with
has part(s)

Identifiers

 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115605&oldid=2022962863"