(Q21115711)

English

Copine 1

mammalian protein found in Homo sapiens

copine-1
copine I
CPNE1
chromobindin 17

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99829

von Willebrand factor A-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99829

Copine domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

von Willebrand factor, type A, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Copine, C2B domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

8 April 2019

Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

transporter activity

determination method

1 reference

8 April 2019

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

endopeptidase activity

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

phosphatidylserine binding

determination method

1 reference

8 April 2019

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

NF-kappaB binding

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

protein binding

determination method

1 reference

8 April 2019

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

calcium-dependent phospholipid binding

determination method

1 reference

26 September 2017

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99829&geneProductId=UniProtKB:Q99829

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

8 April 2019

Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

8 April 2019

Copine1 C2 domains have a critical calcium-independent role in the neuronal differentiation of hippocampal progenitor HiB5 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

plasma membrane

determination method

2 references

extracellular exosome

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

8 April 2019

Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

nuclear membrane

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

azurophil granule membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

plasma membrane

determination method

biological process

cellular response to calcium ion

determination method

1 reference

26 September 2017

Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99829&geneProductId=UniProtKB:Q99829

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

positive regulation of protein kinase B signaling

determination method

regulation of transcription, DNA-templated

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99829&geneProductId=UniProtKB:Q99829

determination method

lipid metabolism

determination method

1 reference

8 April 2019

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

positive regulation of tumor necrosis factor-mediated signaling pathway

determination method

1 reference

26 September 2017

Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99829&geneProductId=UniProtKB:Q99829

determination method

negative regulation of DNA binding

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

transcription, DNA-templated

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99829&geneProductId=UniProtKB:Q99829

determination method

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

neuron projection extension

determination method

negative regulation of NIK/NF-kappaB signaling

determination method

1 reference

8 April 2019

Copine-I represses NF-kappaB transcription by endoproteolysis of p65

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

glycerophospholipid biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

positive regulation of neuron differentiation

determination method

vesicle-mediated transport

determination method

1 reference

8 April 2019

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

26 September 2017

Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99829&geneProductId=UniProtKB:Q99829

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99829

determination method

positive regulation of tumor necrosis factor-mediated signaling pathway

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000336945

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000336945

ENSP00000380585

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380585

ENSP00000317257

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000317257

ENSP00000380584

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380584

ENSP00000386067

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386067

ENSP00000387434

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000387434

ENSP00000389662

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389662

ENSP00000390141

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390141

ENSP00000390626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390626

ENSP00000391483

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391483

ENSP00000396069

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396069

ENSP00000397638

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397638

ENSP00000401915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401915

ENSP00000404355

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404355

ENSP00000409305

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409305

ENSP00000409794

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409794

ENSP00000409955

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409955

ENSP00000412806

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412806

ENSP00000415597

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000415597

ENSP00000416962

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416962

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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