(Q21115888)

English

Fas associated factor family member 2

mammalian protein found in Homo sapiens

FAS-associated factor 2
UBX domain-containing protein 8
expressed in T-cells and eosinophils in atopic dermatitis
UBX domain-containing protein 3B
FAF2
UBX domain containing 8
Protein ETEA
UBX domain protein 3B

In more languages

edit

Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

lipase inhibitor activity

1 reference

8 April 2019

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

1 reference

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

5 references

8 April 2019

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

1 reference

8 April 2019

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IDA

ubiquitin protein ligase binding

1 reference

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IDA

cell component

VCP-NPL4-UFD1 AAA ATPase complex

1 reference

8 April 2019

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IDA

endoplasmic reticulum

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

TAS

azurophil granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

TAS

biological process

response to unfolded protein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IEA

retrograde protein transport, ER to cytosol

1 reference

8 April 2019

Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IMP

ubiquitin-dependent ERAD pathway

1 reference

8 April 2019

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IMP

lipid droplet organization

1 reference

8 April 2019

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IMP

negative regulation of catalytic activity

1 reference

8 April 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

IEA

neutrophil degranulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

determination method

TAS

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96CS3

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q96CS3

UBX domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q96CS3

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

9 August 2016

language of work or name

English

(Q21115888)

Fas associated factor family member 2

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)