(Q21115925)

English

RAD17 checkpoint clamp loader component

mammalian protein found in Homo sapiens

cell cycle checkpoint protein RAD17
RAD17 homolog
RF-C/activator 1 homolog
cell cycle checkpoint protein (RAD17)
RAD17
Rad17-like protein
RAD1 homolog
RF-C activator 1 homolog

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Statements

1 reference

13 November 2019

Checkpoint protein Rad17/Rad24, fungi/metazoa

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75943

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75943

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

5 references

8 April 2019

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

1 reference

8 April 2019

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IDA

Rad17 RFC-like complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

1 reference

8 April 2019

HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IDA

biological process

mitotic cell cycle checkpoint signaling

1 reference

8 April 2019

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IMP

DNA replication checkpoint signaling

1 reference

8 April 2019

Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IEA

regulation of phosphorylation

1 reference

8 April 2019

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IMP

negative regulation of DNA replication

1 reference

8 April 2019

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IMP

cellular response to DNA damage stimulus

3 references

8 April 2019

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IEA

mitotic DNA replication checkpoint signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

3 references

DNA damage checkpoint signaling

3 references

8 April 2019

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

IBA

regulation of signal transduction by p53 class mediator

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75943

determination method

TAS

Identifiers

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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1 reference

15 October 2015

http://www.uniprot.org/uniprot/O60671.txt?132

1 reference

15 October 2015

http://www.uniprot.org/uniprot/O60671.txt?132

1 reference

15 October 2015

http://www.uniprot.org/uniprot/O60671.txt?132

stated in

UniProt

(Q21115925)

RAD17 checkpoint clamp loader component

Statements

Identifiers

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