Wikidata

(Q21115982)

English

SUZ12 polycomb repressive complex 2 subunit

mammalian protein found in Homo sapiens

  • suppressor of zeste 12 protein homolog
  • joined to JAZF1 protein
  • SUZ12
  • chromatin precipitated E2F target 9 protein
  • chET 9 protein
  • polycomb protein SUZ12
In more languages

Statements

molecular function
protein binding
determination method
IPI
17 references
retrieved
8 April 2019
stated in
Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome
GOA
curator
UniProt
UniProt protein ID
Q15022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27
GOA
curator
UniProt
UniProt protein ID
Q15022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
GOA
curator
UniProt
UniProt protein ID
Q15022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
The histone variant macroH2A is an epigenetic regulator of key developmental genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
retrieved
8 April 2019
stated in
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IPI
cell component
ESC/E(Z) complex
determination method
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IEA
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
UniProt
UniProt protein ID
Q15022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IDA
retrieved
8 April 2019
stated in
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
GOA
curator
UniProt
UniProt protein ID
Q15022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IDA
retrieved
8 April 2019
stated in
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
GOA
curator
UniProt
UniProt protein ID
Q15022
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15022
determination method
IBA
biological process

Identifiers

 
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