Wikidata

(Q21116206)

English

Cytohesin 2

mammalian protein found in Homo sapiens

  • pleckstrin homology, Sec7 and coiled-coil domains 2
  • ARF exchange factor
  • ARF nucleotide-binding site opener
  • Protein ARNO
  • cytohesin-2
  • pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)
  • PH, SEC7 and coiled-coil domain-containing protein 2
  • CYTH2
  • CTC-273B12.8
In more languages

Statements

molecular function
protein binding
determination method
IPI
12 references
retrieved
8 April 2019
stated in
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration
GOA
curator
UniProt
UniProt protein ID
Q99418
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
GOA
curator
UniProt
UniProt protein ID
Q99418
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q99418
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99418
determination method
IPI
cell component

Identifiers

 
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