Wikidata

(Q21116233)

English

Basic helix-loop-helix family member e40

mammalian protein found in Homo sapiens

  • class B basic helix-loop-helix protein 2
  • enhancer-of-split and hairy-related protein 2
  • basic helix-loop-helix domain containing, class B, 2
  • DEC1
  • bHLHb2
  • differentially expressed in chondrocytes protein 1
  • SHARP-2
  • BHLHE40
  • stimulated by retinoic acid gene 13 protein
  • differentially expressed in chondrocytes 1
  • class E basic helix-loop-helix protein 40
  • differentiated embryo chondrocyte expressed gene 1
In more languages

Statements

molecular function
DNA-binding transcription repressor activity, RNA polymerase II-specific
determination method
IDA
IEA
6 references
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IEA
retrieved
27 March 2018
stated in
DEC1 modulates the circadian phase of clock gene expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
27 March 2018
stated in
DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
27 March 2018
stated in
DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IEA
retrieved
10 September 2018
stated in
Dec1 and Dec2 are regulators of the mammalian molecular clock
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
E-box binding
determination method
IDA
IEA
7 references
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IEA
retrieved
7 November 2018
stated in
A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
Dec1 and Dec2 are regulators of the mammalian molecular clock
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
DEC1 modulates the circadian phase of clock gene expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
protein binding
determination method
IPI
9 references
retrieved
7 November 2018
stated in
The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
GOA
curator
UniProt
UniProt protein ID
O14503
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Dec1 and Dec2 are regulators of the mammalian molecular clock
GOA
curator
UniProt
UniProt protein ID
O14503
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
retrieved
7 November 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IPI
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method
IDA
IEA
ISA
ISM
ISS
NAS
6 references
retrieved
7 November 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
NAS
retrieved
7 November 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
ISS
retrieved
7 November 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
ISM
retrieved
7 November 2018
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
ISA
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IEA
retrieved
7 November 2018
stated in
Dec1 and Dec2 are regulators of the mammalian molecular clock
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
DNA-binding transcription repressor activity, RNA polymerase II-specific
determination method
IBA
IDA
IEA
11 references
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IEA
retrieved
10 September 2018
stated in
DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
10 September 2018
stated in
DEC1 modulates the circadian phase of clock gene expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
10 September 2018
stated in
DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IBA
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IEA
retrieved
7 November 2018
stated in
DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
DEC1 modulates the circadian phase of clock gene expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
Dec1 and Dec2 are regulators of the mammalian molecular clock
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IDA
retrieved
7 November 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O14503&geneProductId=UniProtKB:O14503
determination method
IBA
cell component
biological process

Identifiers

 
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