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(Q21116352)
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English
AF4/FMR2 family member 1
mammalian protein found in Homo sapiens
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2
pre-B-cell monocytic leukemia partner 1
ALL1-fused gene from chromosome 4 protein
AFF1
Protein FEL
Protein AF-4
proto-oncogene AF4
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P51825
part of
Transcription factor AF4/FMR2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P51825
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P51825
encoded by
AFF1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P51825
molecular function
DNA-binding transcription factor activity
determination method
TAS
1 reference
retrieved
24 April 2018
stated in
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51825&geneProductId=UniProtKB:P51825
determination method
TAS
protein binding
determination method
IPI
3 references
retrieved
8 April 2019
stated in
Human mediator subunit MED26 functions as a docking site for transcription elongation factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IPI
retrieved
8 April 2019
stated in
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IPI
double-stranded DNA binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IBA
DNA-binding transcription factor activity
determination method
IBA
TAS
2 references
retrieved
8 April 2019
stated in
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
TAS
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IBA
cell component
nucleus
determination method
IEA
1 reference
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P51825
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51825&geneProductId=UniProtKB:P51825
determination method
IEA
transcription elongation factor complex
determination method
IDA
1 reference
retrieved
24 April 2018
stated in
The little elongation complex regulates small nuclear RNA transcription
GOA
curator
UniProt
UniProt protein ID
P51825
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51825&geneProductId=UniProtKB:P51825
determination method
IDA
nucleus
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P51825
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IBA
transcription elongation factor complex
determination method
IBA
IDA
2 references
retrieved
8 April 2019
stated in
The little elongation complex regulates small nuclear RNA transcription
GOA
curator
UniProt
UniProt protein ID
P51825
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IBA
super elongation complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IBA
biological process
regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51825
determination method
IEA
Identifiers
RefSeq protein ID
NP_001160165
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
NP_001300888
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
NP_001300889
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
NP_005926
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_005263064
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_005263066
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_005263068
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_005263070
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_011530275
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_016863704
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
XP_016863705
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4299
UniProt protein ID
P51825
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P51825
Ensembl protein ID
ENSP00000305689
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000305689
ENSP00000378578
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000378578
ENSP00000424483
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000424483
ENSP00000424766
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000424766
ENSP00000424881
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000424881
ENSP00000425755
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000425755
ENSP00000427593
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000427593
ENSP00000440843
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000440843
ENSP00000501252
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000501252
PDB structure ID
2LM0
1 reference
stated in
UniProt
UniProt protein ID
P51825
retrieved
4 August 2016
language of work or name
English
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