(Q21117125)

English

Tau tubulin kinase 2

mammalian protein found in Homo sapiens

tau-tubulin kinase 2
Protein bartleby
TTBK2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6IQ55

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

protein kinase activity

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6IQ55&geneProductId=UniProtKB:Q6IQ55

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

protein serine/threonine kinase activity

determination method

protein binding

determination method

4 references

8 April 2019

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

determination method

2 references

protein serine/threonine kinase activity

determination method

4 references

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

kinesin binding

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

tau protein binding

determination method

1 reference

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

microtubule plus-end binding

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6IQ55&geneProductId=UniProtKB:Q6IQ55

determination method

ciliary basal body

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6IQ55&geneProductId=UniProtKB:Q6IQ55

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

extracellular space

determination method

1 reference

26 September 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6IQ55&geneProductId=UniProtKB:Q6IQ55

determination method

extracellular space

determination method

1 reference

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

ciliary transition zone

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

biological process

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

cell projection organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

peptidyl-serine phosphorylation

determination method

1 reference

26 September 2017

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6IQ55&geneProductId=UniProtKB:Q6IQ55

determination method

smoothened signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

regulation of cell shape

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6IQ55&geneProductId=UniProtKB:Q6IQ55

determination method

ciliary basal body-plasma membrane docking

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

microtubule cytoskeleton organization

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

negative regulation of microtubule depolymerization

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

peptidyl-serine phosphorylation

determination method

3 references

8 April 2019

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

peptidyl-threonine phosphorylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

cerebellum development

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

cerebellar granular layer development

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

cerebellar granule cell precursor tangential migration

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

regulation of cell migration

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

cilium assembly

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

negative regulation of protein localization to microtubule

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

negative regulation of microtubule binding

determination method

1 reference

8 April 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6IQ55

determination method

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6IQ55

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6IQ55

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000267890

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000267890

ENSP00000455734

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000455734

ENSP00000454605

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000454605

ENSP00000455574

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000455574

ENSP00000457385

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457385

ENSP00000457489

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457489

ENSP00000479984

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479984

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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