(Q21117951)

DnaJ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin interacting motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

DnaJ domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

polyubiquitin modification-dependent protein binding

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 reference

1 January 2018

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 reference

8 April 2019

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

ubiquitin protein ligase binding

IPI

1 reference

1 January 2018

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

ATPase activator activity

IPI

The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation

Hsp70 protein binding

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 January 2018

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

unfolded protein binding

ATPase activator activity

3 references

8 April 2019

Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

8 April 2019

The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

1 reference

8 April 2019

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

unfolded protein binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

8 April 2019

Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

ubiquitin-dependent protein binding

IBA

1 reference

8 April 2019

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 reference

1 January 2018

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 January 2018

The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 January 2018

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

endoplasmic reticulum

1 reference

8 April 2019

endoplasmic reticulum membrane

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

intrinsic component of endoplasmic reticulum membrane

IEA

1 reference

1 January 2018

The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

intrinsic component of endoplasmic reticulum membrane

IEA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

response to unfolded protein

IBA

biological process

1 reference

8 April 2019

Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

negative regulation of protein deubiquitination

TAS

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

positive regulation of protein ubiquitination

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

ubiquitin-dependent ERAD pathway

1 reference

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 reference

1 January 2018

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

negative regulation of inclusion body assembly

3 references

1 January 2018

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 January 2018

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

1 January 2018

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

regulation of protein localization

1 reference

1 January 2018

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

regulation of protein ubiquitination

1 reference

8 April 2019

Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

negative regulation of protein binding

1 reference

8 April 2019

Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

positive regulation of ATP-dependent activity

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

chaperone-mediated protein folding

1 reference

1 January 2018

Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25686&geneProductId=UniProtKB:P25686

regulation of chaperone-mediated protein folding

1 reference

8 April 2019

Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

negative regulation of cell population proliferation

1 reference

8 April 2019

Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

negative regulation of cell growth

IGI

1 reference

8 April 2019

Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

ubiquitin-dependent ERAD pathway

IGI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

neuron cellular homeostasis

IBA

1 reference

8 April 2019

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

negative regulation of inclusion body assembly

TAS

1 reference

8 April 2019

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25686

DnaJ domain, conserved site

has part(s)

1 reference

Ubiquitin interacting motif

1 reference

DnaJ domain

1 reference