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(Q21118584)
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PNKD metallo-beta-lactamase domain containing
mammalian protein found in Homo sapiens
brain protein 17
Paroxysmal nonkinesiogenic dyskinesia protein
trans-activated by hepatitis C virus core protein 2
probable hydrolase PNKD
PNKD, MBL domain containing
myofibrillogenesis regulator 1
MR-1
PNKD
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N490
part of
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N490
Hydroxyacylglutathione hydrolase, subgroup
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N490
Metallo-beta-lactamase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Hydroxyacylglutathione hydrolase, MBL domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Hydroxyacylglutathione hydrolase, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N490
encoded by
PNKD
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N490
molecular function
hydroxyacylglutathione hydrolase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
protein binding
determination method
IPI
3 references
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of myofibrillogenesis regulator-1 activates the MAPK signaling pathway and induces proliferation and migration in human breast cancer MCF7 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IPI
hydrolase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N490
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N490
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N490
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
membrane
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N490
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
retrieved
8 April 2019
stated in
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IDA
mitochondrion
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N490
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IDA
nucleus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N490
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
biological process
regulation of synaptic transmission, dopaminergic
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
negative regulation of neurotransmitter secretion
determination method
IEA
1 reference
retrieved
3 January 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8N490
determination method
IEA
neuromuscular process controlling posture
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
regulation of dopamine metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
negative regulation of neurotransmitter secretion
determination method
IEA
IMP
2 references
retrieved
8 April 2019
stated in
Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis
GOA
curator
SynGO
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N490
determination method
IEA
has part(s)
Metallo-beta-lactamase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N490
Hydroxyacylglutathione hydrolase, C-terminal domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N490
Hydroxyacylglutathione hydrolase, MBL domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N490
Identifiers
RefSeq protein ID
NP_001070867
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25953
NP_056303
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25953
NP_072094
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25953
XP_016859260
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25953
XP_016859261
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25953
UniProt protein ID
Q8N490
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N490
Ensembl protein ID
ENSP00000248451
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000248451
ENSP00000258362
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000258362
ENSP00000273077
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000273077
ENSP00000414400
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000414400
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