(Q21119018)

http://www.ebi.ac.uk/interpro/protein/Q9NZM5

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

26 September 2017

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

10 references

8 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

identical protein binding

IPI

1 reference

8 April 2019

The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

intracellular anatomical structure

IDA

cell component

1 reference

1 January 2018

A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

intracellular membrane-bounded organelle

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

10 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2/PICT-1, a putative tumor suppressor gene product, induces the nucleolar targeting of the Kaposi's sarcoma-associated herpesvirus KS-Bcl-2 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

ribosomal large subunit assembly

IDA

biological process

1 reference

26 September 2017

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

regulation of protein phosphorylation

1 reference

8 April 2019

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

regulation of signal transduction by p53 class mediator

4 references

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

negative regulation of signal transduction by p53 class mediator

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

regulation of aerobic respiration

IEA

1 reference

8 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

ribosomal large subunit export from nucleus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZM5&geneProductId=UniProtKB:Q9NZM5

negative regulation of transcription by RNA polymerase II

IBA

1 reference

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

Involvement of GLTSCR2 in the DNA Damage Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

mitotic G2 DNA damage checkpoint signaling

1 reference

8 April 2019

Involvement of GLTSCR2 in the DNA Damage Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

negative regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

negative regulation of protein-containing complex assembly

1 reference

8 April 2019

The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

3 references

8 April 2019

GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

regulation of apoptotic process

IEA

1 reference

8 April 2019

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus

regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

cellular response to hypoxia

1 reference

8 April 2019

Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

protein localization to nucleolus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

cellular response to DNA damage stimulus

IEA

1 reference

8 April 2019

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

regulation of RIG-I signaling pathway

1 reference

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

negative regulation of protein kinase B signaling

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

1 reference

8 April 2019

PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

positive regulation of protein K63-linked deubiquitination

1 reference

8 April 2019

The nucleolar protein GLTSCR2 is required for efficient viral replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZM5