Wikidata

(Q21119240)

English

Phosphoribosyl pyrophosphate synthetase 1

mammalian protein found in Homo sapiens

  • PRS-I
  • deafness, X-linked 2, perceptive, congenital
  • ribose-phosphate pyrophosphokinase 1
  • PRPS1
  • phosphoribosyl pyrophosphate synthase I
  • PPRibP
  • dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1)
  • ribose-phosphate diphosphokinase 1
  • deafness 2, perceptive, congenital
In more languages

Statements

molecular function
ribose phosphate diphosphokinase activity
determination method
EXP
IDA
IEA
IMP
8 references
retrieved
27 March 2018
stated in
Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IMP
retrieved
27 March 2018
stated in
Arts syndrome is caused by loss-of-function mutations in PRPS1
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IMP
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
27 March 2018
stated in
Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IDA
retrieved
27 March 2018
stated in
Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IDA
retrieved
27 March 2018
stated in
Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
EXP
ribose phosphate diphosphokinase activity
determination method
EXP
IBA
IDA
IEA
IMP
8 references
retrieved
1 January 2018
stated in
Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IMP
retrieved
1 January 2018
stated in
Arts syndrome is caused by loss-of-function mutations in PRPS1
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
1 January 2018
stated in
Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IDA
retrieved
1 January 2018
stated in
Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
IBA
retrieved
1 January 2018
stated in
Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891
determination method
EXP
ribose phosphate diphosphokinase activity
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Arts syndrome is caused by loss-of-function mutations in PRPS1
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IMP
retrieved
8 April 2019
stated in
Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IEA
retrieved
8 April 2019
stated in
Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IDA
retrieved
8 April 2019
stated in
Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)
GOA
curator
UniProt
UniProt protein ID
P60891
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891
determination method
IBA
biological process

Identifiers

 
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