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Pyrroline-5-carboxylate reductase 2
mammalian protein found in Homo sapiens
P5C reductase 2
pyrroline-5-carboxylate reductase family member 2
PYCR2
pyrroline 5-carboxylate reductase isoform
pyrroline-5-carboxylate reductase 2
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96C36
part of
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96C36
NAD(P)-binding domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96C36
Pyrroline-5-carboxylate reductase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96C36
Pyrroline-5-carboxylate reductase, dimerisation domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Pyrroline-5-carboxylate reductase, catalytic, N-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96C36
encoded by
PYCR2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96C36
molecular function
pyrroline-5-carboxylate reductase activity
determination method
EXP
IEA
3 references
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96C36&geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96C36&geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
10 September 2018
stated in
Functional specialization in proline biosynthesis of melanoma
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96C36&geneProductId=UniProtKB:Q96C36
determination method
EXP
oxidoreductase activity
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
protein binding
determination method
IPI
1 reference
retrieved
9 May 2019
stated in
Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IPI
pyrroline-5-carboxylate reductase activity
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
pyrroline-5-carboxylate reductase activity
determination method
IBA
IEA
3 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IBA
cell component
mitochondrial matrix
determination method
TAS
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
TAS
cytoplasm
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
mitochondrion
determination method
IDA
IEA
4 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
9 May 2019
stated in
Functional specialization in proline biosynthesis of melanoma
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IDA
retrieved
9 May 2019
stated in
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IDA
biological process
L-proline biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
cellular response to oxidative stress
determination method
IMP
1 reference
retrieved
9 May 2019
stated in
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IMP
proline biosynthetic process
determination method
IDA
IEA
3 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
9 May 2019
stated in
Functional specialization in proline biosynthesis of melanoma
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IDA
cellular amino acid biosynthetic process
determination method
TAS
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
L-proline biosynthetic process
determination method
IBA
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96C36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96C36
determination method
IBA
has part(s)
Pyrroline-5-carboxylate reductase, dimerisation domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96C36
Pyrroline-5-carboxylate reductase, catalytic, N-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96C36
Identifiers
RefSeq protein ID
NP_001258610
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
29920
NP_037460
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
29920
UniProt protein ID
Q96C36
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96C36
Ensembl protein ID
ENSP00000342502
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000342502
ENSP00000478165
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000478165
ENSP00000480779
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000480779
ENSP00000482614
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000482614
ENSP00000482845
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000482845
Sitelinks
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