(Q21119695)

English

Protein tyrosine phosphatase non-receptor type 13

mammalian protein found in Homo sapiens

PTPN13
tyrosine-protein phosphatase non-receptor type 13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
FAP-1
PTP-BAS
fas-associated protein-tyrosine phosphatase 1
protein-tyrosine phosphatase PTPL1
PTP-E1
hPTPE1
protein-tyrosine phosphatase 1E

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Tyrosine-protein phosphatase non-receptor type 13

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Protein-tyrosine phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

FERM/acyl-CoA-binding protein superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

FERM superfamily, second domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Tyrosine specific protein phosphatases domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM central domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM, C-terminal PH-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTP type protein phosphatase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

KIND domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein tyrosine phosphatase activity

determination method

5 references

8 April 2019

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

phosphatase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

phosphatidylinositol 3-kinase regulatory subunit binding

determination method

1 reference

8 April 2019

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

protein binding

determination method

13 references

8 April 2019

The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Ligand-dependent dynamics and intramolecular signaling in a PDZ domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

8 April 2019

Energetics of peptide recognition by the second PDZ domain of human protein tyrosine phosphatase 1E

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

neuron projection

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

determination method

2 references

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

biological process

peptidyl-tyrosine dephosphorylation

determination method

1 reference

8 April 2019

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

8 April 2019

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

dephosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

phosphatidylinositol biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

negative regulation of protein phosphorylation

determination method

1 reference

8 April 2019

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

cellular response to cytokine stimulus

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12923

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Tyrosine specific protein phosphatases domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

FERM central domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

PTP type protein phosphatase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

FERM, C-terminal PH-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

FERM, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Protein-tyrosine phosphatase, catalytic

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12923

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000322675

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000322675

ENSP00000394794

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000394794

ENSP00000407249

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407249

ENSP00000408368

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408368

ENSP00000426626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426626

ENSP00000422835

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422835

ENSP00000423531

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423531

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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