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(Q21120117)
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Neuronal guanine nucleotide exchange factor
mammalian protein found in Homo sapiens
eph-interacting exchange protein
ephexin-1
ephexin1
NGEF
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N5V2
part of
SH3-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
Dbl homology (DH) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ephexin-1, SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Dbl homology (DH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N5V2
encoded by
NGEF
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N5V2
molecular function
guanyl-nucleotide exchange factor activity
determination method
IEA
EXP
TAS
3 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N5V2&geneProductId=UniProtKB:Q8N5V2
determination method
TAS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N5V2&geneProductId=UniProtKB:Q8N5V2
determination method
IEA
retrieved
5 June 2018
stated in
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N5V2&geneProductId=UniProtKB:Q8N5V2
determination method
EXP
guanyl-nucleotide exchange factor activity
determination method
EXP
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
retrieved
8 April 2019
stated in
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
EXP
cell component
growth cone
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
TAS
cell projection
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
biological process
regulation of GTPase activity
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
ISS
ephrin receptor signaling pathway
determination method
ISS
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
ISS
multicellular organism development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
cell differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
regulation of Rho protein signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
regulation of small GTPase mediated signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
TAS
negative regulation of dendritic spine morphogenesis
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
ISS
nervous system development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8N5V2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
IEA
positive regulation of apoptotic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
TAS
G protein-coupled receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N5V2
determination method
TAS
has part(s)
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
Dbl homology (DH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
Ephexin-1, SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8N5V2
Identifiers
RefSeq protein ID
NP_001107562
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25791
NP_062824
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25791
XP_011509225
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25791
XP_011509226
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25791
XP_011509227
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
25791
UniProt protein ID
Q8N5V2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8N5V2
Ensembl protein ID
ENSP00000264051
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000264051
ENSP00000362653
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000362653
ENSP00000387033
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000387033
ENSP00000387591
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000387591
ENSP00000401063
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000401063
ENSP00000405053
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000405053
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