(Q21120178)

http://www.ebi.ac.uk/interpro/protein/Q96DE0

NUDIX hydrolase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

dIDP diphosphatase activity

1 reference

1 January 2018

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

m7G(5')pppN diphosphatase activity

EXP

5 references

8 April 2019

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

protein homodimerization activity

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

identical protein binding

1 reference

8 April 2019

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

metalloexopeptidase activity

IPI

1 reference

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

magnesium ion binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

inosine-diphosphatase activity

1 reference

1 January 2018

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

dITP diphosphatase activity

EXP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

phosphodiesterase decapping endonuclease activity

1 reference

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

2 references

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

26 September 2017

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

26 September 2017

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

26 September 2017

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96DE0&geneProductId=UniProtKB:Q96DE0

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

positive regulation of double-strand break repair

HDA

biological process

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

nucleobase-containing small molecule catabolic process

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

TAS

IDP catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

nucleotide metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

sno(s)RNA catabolic process

4 references

8 April 2019

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

8 April 2019

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

negative regulation of rRNA processing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

positive regulation of cell cycle process

ISS

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

positive regulation of cell population proliferation

IMP

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

adenosine to inosine editing

IMP

1 reference

8 April 2019

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

dITP catabolic process

1 reference

8 April 2019

RNA phosphodiester bond hydrolysis, endonucleolytic

ISS

1 reference

8 April 2019

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96DE0

http://www.uniprot.org/uniprot/Q96DE0.txt?version=118

EC enzyme number

3.6.1.64

1 reference

6 January 2016

has part(s)

NUDIX hydrolase domain

1 reference

stated in

InterPro Release 71.0