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Hes family bHLH transcription factor 2
mammalian protein found in Homo sapiens
transcription factor HES-2
class B basic helix-loop-helix protein 40
hairy and enhancer of split 2
HES2
bHLHb40
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y543
part of
Helix-loop-helix DNA-binding domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y543
Myc-type, basic helix-loop-helix (bHLH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Orange domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y543
encoded by
HES2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y543
molecular function
DNA binding
determination method
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
double-stranded DNA binding
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
transcription factor binding
determination method
NAS
1 reference
retrieved
9 May 2019
stated in
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer
GOA
curator
UniProt
UniProt protein ID
Q9Y543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
NAS
protein dimerization activity
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
RNA polymerase II cis-regulatory region sequence-specific DNA binding
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
DNA-binding transcription repressor activity, RNA polymerase II-specific
determination method
IEA
2 references
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y543&geneProductId=UniProtKB:Q9Y543
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method
ISA
ISM
NAS
3 references
retrieved
9 May 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
NAS
retrieved
9 May 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
ISM
retrieved
9 May 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
ISA
RNA polymerase II transcription regulatory region sequence-specific DNA binding
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
DNA-binding transcription repressor activity, RNA polymerase II-specific
determination method
IBA
IEA
4 references
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y543&geneProductId=UniProtKB:Q9Y543
determination method
IEA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y543&geneProductId=UniProtKB:Q9Y543
determination method
IBA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
transcription corepressor activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
transcription factor binding
determination method
IBA
NAS
2 references
retrieved
8 April 2019
stated in
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer
GOA
curator
UniProt
UniProt protein ID
Q9Y543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
NAS
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
sequence-specific DNA binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
sequence-specific double-stranded DNA binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
cell component
nucleus
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y543&geneProductId=UniProtKB:Q9Y543
determination method
IEA
nucleus
determination method
IBA
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
biological process
negative regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
transcription, DNA-templated
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9Y543
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y543&geneProductId=UniProtKB:Q9Y543
determination method
IEA
negative regulation of transcription by RNA polymerase II
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
somitogenesis
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
Notch signaling pathway
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
cell differentiation
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
regulation of neurogenesis
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
negative regulation of transcription by RNA polymerase II
determination method
IBA
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
anterior/posterior pattern specification
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y543
determination method
IBA
has part(s)
Orange domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y543
Myc-type, basic helix-loop-helix (bHLH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9Y543
Identifiers
RefSeq protein ID
NP_061962
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
54626
UniProt protein ID
Q9Y543
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9Y543
Ensembl protein ID
ENSP00000367065
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000367065
ENSP00000367067
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000367067
ENSP00000367068
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000367068
ENSP00000465248
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000465248
ENSP00000465270
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000465270
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