(Q21120657)

http://www.ebi.ac.uk/interpro/protein/Q9NPF7

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NPF7

0 references

1 reference

13 November 2019

1 reference

13 November 2019

5 references

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

interleukin-23 receptor binding

IPI

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

endoplasmic reticulum lumen

IBA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

interleukin-23 complex

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

negative regulation of interleukin-10 production

IBA

biological process

1 reference

8 April 2019

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of inflammatory response

IMP

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of interleukin-12 production

IC

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of interleukin-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

immune system process

1 reference

8 April 2019

positive regulation of interferon-gamma production

4 references

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of natural killer cell activation

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of osteoclast differentiation

IC

1 reference

8 April 2019

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of T-helper 17 cell lineage commitment

positive regulation of NK T cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of natural killer cell proliferation

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of NK T cell proliferation

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

defense response to virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of tissue remodeling

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of T-helper 1 type immune response

IC

5 references

8 April 2019

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of granulocyte macrophage colony-stimulating factor production

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

defense response to Gram-negative bacterium

positive regulation of T cell proliferation

1 reference

27 March 2018

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NPF7&geneProductId=UniProtKB:Q9NPF7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of neutrophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of interleukin-17 production

IMP

3 references

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

8 April 2019

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

innate immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

inflammatory response

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of activated T cell proliferation

1 reference

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of defense response to virus by host

positive regulation of activation of Janus kinase activity

1 reference

27 March 2018

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NPF7&geneProductId=UniProtKB:Q9NPF7

regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of tyrosine phosphorylation of STAT protein

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

interleukin-23-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7

positive regulation of activation of Janus kinase activity

IBA

physically interacts with

tildrakizumab

object of statement has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2108681

different from

interleukin 23

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

0 references

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016