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(Q21121545)
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Protein phosphatase 1 regulatory inhibitor subunit 1B
mammalian protein found in Homo sapiens
protein phosphatase 1 regulatory subunit 1B
DARPP-32
dopamine and cAMP-regulated neuronal phosphoprotein 32
Dopamine- and cAMP-regulated neuronal phosphoprotein
PPP1R1B
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UD71
part of
Protein phosphatase 1 regulatory subunit 1B
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9UD71
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UD71
encoded by
PPP1R1B
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UD71
molecular function
protein serine/threonine phosphatase inhibitor activity
determination method
IBA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UD71&geneProductId=UniProtKB:Q9UD71
determination method
IBA
protein kinase inhibitor activity
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
GOA
curator
UniProt
UniProt protein ID
Q9UD71
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
TAS
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IPI
cAMP-dependent protein kinase inhibitor activity
determination method
TAS
1 reference
retrieved
10 September 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UD71&geneProductId=UniProtKB:Q9UD71
determination method
TAS
protein phosphatase regulator activity
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
TAS
protein phosphatase inhibitor activity
determination method
IDA
IEA
TAS
4 references
retrieved
8 April 2019
stated in
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
GOA
curator
UniProt
UniProt protein ID
Q9UD71
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UD71
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
retrieved
8 April 2019
stated in
Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IDA
D1 dopamine receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
D2 dopamine receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
D3 dopamine receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
D4 dopamine receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
D5 dopamine receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
cell component
cytoplasm
determination method
IBA
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UD71
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IBA
neuronal cell body
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
nucleus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
cytosol
determination method
IEA
TAS
2 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
dendritic spine neck
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
dendritic spine head
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
postsynapse
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
glutamatergic synapse
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
TAS
biological process
visual learning
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
intracellular signal transduction
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IBA
response to amphetamine
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
transcription, DNA-templated
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
negative regulation of female receptivity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
signal transduction
determination method
TAS
IEA
2 references
retrieved
8 April 2019
stated in
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
GOA
curator
UniProt
UniProt protein ID
Q9UD71
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
negative regulation of protein kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
negative regulation of protein serine/threonine kinase activity
determination method
IEA
1 reference
retrieved
10 September 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UD71&geneProductId=UniProtKB:Q9UD71
determination method
IEA
negative regulation of phosphoprotein phosphatase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IDA
locomotory behavior
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
response to morphine
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
behavioral response to cocaine
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
response to cocaine
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
memory
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
response to nicotine
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UD71
determination method
IEA
Identifiers
RefSeq protein ID
NP_001229393
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
84152
NP_115568
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
84152
NP_852606
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
84152
XP_016880705
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
84152
XP_016880706
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
84152
UniProt protein ID
Q9UD71
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9UD71
Ensembl protein ID
ENSP00000254079
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000254079
ENSP00000377808
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000377808
ENSP00000377810
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000377810
ENSP00000462137
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000462137
ENSP00000462522
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000462522
ENSP00000462841
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000462841
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