(Q21121602)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15027

Sec16, central conserved domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ancestral coatomer element 1, Sec16/Sec31, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

9 references

8 April 2019

Characterization of human Sec16B: indications of specialized, non-redundant functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Sec16A is critical for both conventional and unconventional secretion of CFTR.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Nbeal2 interacts with Dock7, Sec16a, and Vac14.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

cell component

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

8 April 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15027&geneProductId=UniProtKB:O15027

1 reference

26 September 2017

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

8 April 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

8 April 2019

Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

ER to Golgi transport vesicle membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

8 April 2019

perinuclear region of cytoplasm

endoplasmic reticulum exit site

ISS

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Characterization of human Sec16B: indications of specialized, non-redundant functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Sec16A is critical for both conventional and unconventional secretion of CFTR.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

endoplasmic reticulum exit site

Ensembl genome database project

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Sec16A is critical for both conventional and unconventional secretion of CFTR.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Characterization of human Sec16B: indications of specialized, non-redundant functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

biological process

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

8 April 2019

substantia nigra development

IEP

1 reference

26 September 2017

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15027&geneProductId=UniProtKB:O15027

vesicle-mediated transport

IEP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

8 April 2019

endoplasmic reticulum organization

1 reference

26 September 2017

Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15027&geneProductId=UniProtKB:O15027

transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15027&geneProductId=UniProtKB:O15027

1 reference

26 September 2017

endoplasmic reticulum to Golgi vesicle-mediated transport

1 reference

8 April 2019

Characterization of human Sec16B: indications of specialized, non-redundant functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

endoplasmic reticulum organization

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

Golgi organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

substantia nigra development

HEP

1 reference

8 April 2019

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

protein exit from endoplasmic reticulum

HEP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

1 January 2018

response to endoplasmic reticulum stress

ISS

1 reference

8 April 2019

Sec16A is critical for both conventional and unconventional secretion of CFTR.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

Golgi to plasma membrane CFTR protein transport

1 reference

8 April 2019

Sec16A is critical for both conventional and unconventional secretion of CFTR.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

COPII vesicle coating

TAS

protein stabilization

1 reference

8 April 2019

Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

positive regulation of protein exit from endoplasmic reticulum

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

protein localization to endoplasmic reticulum exit site

protein localization to plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

1 reference

1 January 2018

endoplasmic reticulum organization

ISS

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15027

Sec16, central conserved domain

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15027

Ancestral coatomer element 1, Sec16/Sec31

1 reference

InterPro Release 71.0