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(Q21122356)
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English
Lysosomal trafficking regulator
mammalian protein found in Homo sapiens
beige homolog
Chediak-Higashi syndrome 1
lysosomal-trafficking regulator
LYST
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q99698
part of
WD40/YVTN repeat-like-containing domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
BEACH domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
Armadillo-type fold
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
WD40-repeat-containing domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
Lysosomal-trafficking regulator
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
PH-BEACH domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
BEACH domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
WD40 repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
WD40 repeat, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q99698
encoded by
LYST
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q99698
molecular function
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IPI
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IEA
microtubule cytoskeleton
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IDA
biological process
protein transport
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IEA
pigmentation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IMP
melanosome organization
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
ISS
endosome to lysosome transport via multivesicular body sorting pathway
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IMP
lysosome organization
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IEA
defense response to bacterium
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
ISS
defense response to virus
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
ISS
leukocyte chemotaxis
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
ISS
natural killer cell mediated cytotoxicity
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IMP
retrieved
8 April 2019
stated in
Chediak-Higashi gene in humans. I. Impairment of natural - killer function
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
IMP
mast cell secretory granule organization
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
ISS
defense response to protozoan
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q99698
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99698
determination method
ISS
has part(s)
WD40 repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
BEACH domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
PH-BEACH domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
WD40 repeat, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q99698
Identifiers
RefSeq protein ID
NP_000072
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
NP_001288294
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542333
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542334
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542335
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542336
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542337
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542338
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542339
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_011542341
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_016855639
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
XP_016855640
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
1130
UniProt protein ID
Q99698
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q99698
Ensembl protein ID
ENSP00000374443
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000374443
ENSP00000374444
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000374444
ENSP00000417168
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000417168
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