(Q21122404)

English

MORC family CW-type zinc finger 2

mammalian protein found in Homo sapiens

ATPase MORC2
MORC2
zinc finger CW-type coiled-coil domain protein 1
MORC family CW-type zinc finger protein 2

In more languages

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Statements

1 reference

13 November 2019

Histidine kinase/HSP90-like ATPase superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9Y6X9

Zinc finger, CW-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Histidine kinase/HSP90-like ATPase family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6X9&geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

determination method

IPI

magnesium ion binding

1 reference

8 April 2019

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

14 January 2019

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6X9&geneProductId=UniProtKB:Q9Y6X9

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

8 April 2019

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

8 April 2019

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

determination method

IDA

protein homodimerization activity

1 reference

8 April 2019

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

8 April 2019

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6X9&geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

14 January 2019

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6X9&geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

determination method

IEA

biological process

fatty acid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

determination method

IEA

cellular response to DNA damage stimulus

1 reference

8 April 2019

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

determination method

IDA

negative regulation of gene expression, epigenetic

determination method

IDA

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6X9&geneProductId=UniProtKB:Q9Y6X9

determination method

ISS

positive regulation of DNA methylation-dependent heterochromatin assembly

1 reference

8 April 2019

MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6X9

determination method

IDA

has part(s)

Histidine kinase/HSP90-like ATPase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9Y6X9

Zinc finger, CW-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9Y6X9

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

(Q21122404)

MORC family CW-type zinc finger 2

Statements

Identifiers

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