(Q21123244)

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

1 reference

8 April 2019

Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

protein kinase B binding

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

2 references

8 April 2019

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

phosphoric diester hydrolase activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

3',5'-cyclic-nucleotide phosphodiesterase activity

5 references

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

3',5'-cyclic-AMP phosphodiesterase activity

EXP

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

3',5'-cyclic-GMP phosphodiesterase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

3',5'-cyclic-AMP phosphodiesterase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

integral component of membrane

IBA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

31 October 2017

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

IDA

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

guanyl-nucleotide exchange factor complex

ISS

1 reference

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

negative regulation of cell adhesion

HDA

biological process

1 reference

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP

IMP

cAMP catabolic process

2 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

31 October 2017

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

negative regulation of cAMP-mediated signaling

IEP

1 reference

31 October 2017

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13370&geneProductId=UniProtKB:Q13370

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

cellular response to insulin stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

negative regulation of angiogenesis

ISS

1 reference

8 April 2019

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

negative regulation of lipid catabolic process

IMP

1 reference

8 April 2019

Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

negative regulation of cell adhesion mediated by integrin

IMP

1 reference

8 April 2019

Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13370

negative regulation of cAMP-mediated signaling

IBA

physically interacts with

1 reference

5167

17 August 2016

1 reference

7148

guanosine cyclic 3',5'-phosphate

English

retrieved

17 August 2016

has use

enzyme inhibitor

1 reference

2347

17 August 2016

1 reference

7202

17 August 2016

1 reference

5225

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2051955

has part(s)

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

HD/PDEase domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016