(Q21123577)

P-loop containing nucleoside triphosphate hydrolase

1 reference

ATPase, AAA-type, core domain, protein family

1 reference

MIT domain, protein family

1 reference

AAA proteins

1 reference

Vps4 oligomerisation, C-terminal domain, protein family

1 reference

ATPase, AAA-type, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

protein domain specific binding

IEA

1 reference

8 April 2019

Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

microtubule-severing ATPase activity

IPI

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

protein C-terminus binding

IBA

1 reference

8 April 2019

ESCRT-III recognition by VPS4 ATPases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

14 references

8 April 2019

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

The Protein Network of HIV Budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Essential role of hIST1 in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Biochemical analyses of human IST1 and its function in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ESCRT-III recognition by VPS4 ATPases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

3 references

8 April 2019

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

3 January 2017

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 references

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

protein-containing complex binding

IBA

1 reference

8 April 2019

Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

3 references

8 April 2019

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

3 January 2017

Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

late endosome membrane

1 reference

8 April 2019

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 January 2017

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 January 2017

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 January 2017

Biochemical analyses of human IST1 and its function in cytokinesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

perinuclear region of cytoplasm

1 reference

8 April 2019

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

3 January 2017

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

1 reference

8 April 2019

Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

5 references

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

Biochemical analyses of human IST1 and its function in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

late endosomal microautophagy

biological process

1 reference

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles

ISS

endosomal vesicle fusion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

viral release from host cell

1 reference

3 January 2017

Structural and mechanistic studies of VPS4 proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

1 reference

8 April 2019

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

viral budding via host ESCRT complex

1 reference

8 April 2019

ESCRT requirements for EIAV budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

regulation of protein localization

1 reference

3 January 2017

Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

intracellular cholesterol transport

1 reference

8 April 2019

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

ESCRT complex disassembly

1 reference

8 April 2019

The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

vesicle budding from membrane

NAS

1 reference

8 April 2019

ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

1 reference

8 April 2019

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

positive regulation of viral life cycle

IEA

3 references

3 January 2017

Structural and mechanistic studies of VPS4 proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 January 2017

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 January 2017

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

1 reference

8 April 2019

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

negative regulation of cytokinesis

IEA

1 reference

8 April 2019

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

septum digestion after cytokinesis

1 reference

3 January 2017

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

mitotic metaphase plate congression

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

positive regulation of exosomal secretion

1 reference

8 April 2019

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

vesicle-mediated transport

1 reference

8 April 2019

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

regulation of protein localization to plasma membrane

1 reference

8 April 2019

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

cytoplasmic microtubule organization

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UN37

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

8 April 2019

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

positive regulation of viral budding via host ESCRT complex

NAS

1 reference

8 April 2019

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

actomyosin contractile ring contraction

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

protein targeting to lysosome

TAS

1 reference

8 April 2019

Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

nuclear envelope organization

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

nuclear membrane reassembly

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

regulation of protein localization

TAS

1 reference

8 April 2019

Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

mitotic cytokinesis checkpoint signaling

1 reference

8 April 2019

ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

cytoskeleton-dependent cytokinesis

1 reference

8 April 2019

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

8 April 2019

Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UN37

1 reference

ATPase, AAA-type, conserved site

1 reference

Vps4 oligomerisation, C-terminal

1 reference

AAA+ ATPase domain

1 reference

ATPase, AAA-type, core

1 reference