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(Q21124387)
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English
R-spondin 4
mammalian protein found in Homo sapiens
roof plate-specific spondin-4
R-spondin family, member 4
hRspo4
RSPO4
R-spondin-4
In more languages
default values for all languages
No label defined
No description defined
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2I0M5
part of
Growth factor receptor cysteine-rich domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q2I0M5
Thrombospondin type-1 (TSP1) repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
Furin-like repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2I0M5
encoded by
RSPO4
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2I0M5
molecular function
heparin binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2I0M5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IEA
frizzled binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IBA
cell component
extracellular region
determination method
NAS
TAS
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
TAS
retrieved
8 April 2019
stated in
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2I0M5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IEA
extracellular space
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IBA
biological process
Wnt signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2I0M5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IEA
positive regulation of Wnt signaling pathway
determination method
NAS
1 reference
retrieved
10 September 2018
stated in
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q2I0M5&geneProductId=UniProtKB:Q2I0M5
determination method
NAS
response to stimulus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2I0M5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IEA
nail development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IMP
positive regulation of canonical Wnt signaling pathway
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IBA
positive regulation of Wnt signaling pathway
determination method
IDA
NAS
2 references
retrieved
8 April 2019
stated in
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
NAS
retrieved
8 April 2019
stated in
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
GOA
curator
UniProt
UniProt protein ID
Q2I0M5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2I0M5
determination method
IDA
has part(s)
Thrombospondin type-1 (TSP1) repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q2I0M5
Furin-like repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q2I0M5
Identifiers
RefSeq protein ID
NP_001025042
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
343637
NP_001035096
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
343637
XP_016883328
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
343637
UniProt protein ID
Q2I0M5
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2I0M5
Ensembl protein ID
ENSP00000217260
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000217260
ENSP00000383475
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000383475
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