(Q21124389)

English

R-spondin 1

mammalian protein found in Homo sapiens

R-spondin-1
RSPO1
R-spondin homolog
roof plate-specific spondin-1
hRspo1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Thrombospondin type-1 (TSP1) repeat superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q2MKA7

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q2MKA7

Thrombospondin type-1 (TSP1) repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Furin-like repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

heparin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

protein binding

determination method

6 references

8 April 2019

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

G protein-coupled receptor binding

determination method

1 reference

8 April 2019

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

frizzled binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

extracellular region

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

extracellular space

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

biological process

positive regulation of Wnt signaling pathway

determination method

3 references

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

regulation of receptor internalization

determination method

1 reference

8 April 2019

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

positive regulation of protein phosphorylation

determination method

1 reference

8 April 2019

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

response to stimulus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

positive regulation of canonical Wnt signaling pathway

determination method

3 references

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2MKA7

determination method

Thrombospondin type-1 (TSP1) repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q2MKA7

Furin-like repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q2MKA7

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000348944

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348944

ENSP00000383846

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383846

ENSP00000479832

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479832

ENSP00000481178

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481178

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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